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Jakobsson HE, Rodrguez-Pieiro AM, Schtte A, Ermund A, Boysen P, Bemark M, Sommer F, Bckhed F, Hansson GC, Johansson ME

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In Alzheimer's disease (AD), there are 2 well-characterized abnormal peptide/proteins that include extraneuronal deposition of the amyloid -protein (A) in the form of plaques and intraneuronal deposition of the microtubule-associated protein in the form of filaments

For example, lactylation of apolipoprotein C-II (APOC2) at lysine 70 prevents its degradation and stabilizes the protein, leading to free fatty acid (FFA) release and accumulation in regulatory T cells