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Aging naturally lowers production, while illnesses, infections, and certain medications speed up depletionmaking it vital to adopt habits that help preserve healthy levels

Vet Microbiol 248:108806 ZhuY L, Pilon-Smits EA, Jouanin L, Terry N (1999) Overexpression of glutathione synthetase in Indian mustard enhances cadmium accumulation and tolerance

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This nuclear localization in elderly Leydig cells correlated with reduced expression of 3-HSD, a crucial enzyme for testosterone synthesis, suggesting a link between nuclear FOXO4 and age-related decline in testosterone production [2]