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Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the offspring rats
One notable example is orforglipron (LY3502970), a small molecule in Phase III trial, binds to GLP-1R at a distinct site closer to the extracellular side of the transmembrane helical bundle rather than deeply within the orthosteric pocket (Kawai et al., 2020
Marker proteins of different neuronal subtypes are highlighted in blue
In Hauser's trial no patient withdrew because of adverse effects
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