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In addition, it has been proposed that the reduced sensitivity and drug resistance to KIT inhibitors partially result from the hyperactivation of MAPK caused by the loss of SPRED1 a model verified in human melanoma cell lines and in vivo zebrafish model (101), but presently untested in mouse models and patient samples

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It recruited 502,713 people (intended to be aged 4069 years, mean age 56.5 years, 45.6% men) from 2006 to 2010 in England, Scotland, and Wales, 94% of self-reported European ancestry