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Patients and clinicians may not be alert to suspect non-pigmented lesions as melanoma and so amelanotic melanomas are often misdiagnosed

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The most well-documented false positive culprits include ibuprofen and certain NSAIDs producing false cannabinoid positives on some older assays, quinolone antibiotics like levofloxacin producing false opioid positives, pseudoephedrine (found in many cold medications) producing false amphetamine positives, ranitidine producing false methamphetamine positives on some immunoassays, sertraline and certain other antidepressants producing false benzodiazepine or amphetamine positives on some platforms, and dextromethorphan producing false PCP positives

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