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Full hormone optimization may take up to six months

Por accin de la enzima trimetil lisina dioxigenasa (TML-DO, EC 1.14.11.8) se hidroxila la posicin 3 de la TML para formar la 3-hidroxi- N 6 , N 6 -trimetil lisina ( HTML ) en presencia de oxgeno diatmico como agente oxidante, -cetoglutarato como aceptor de electrones, adems de hierro (II) y cido ascrbico como cofactores

The main difference is bioavailability at the target tissue

doi: 10.1016/j.mrrev.2009.12.005 117 KasaiH

They note, however, that there are promising signs that we may be able to develop medications to help, such as a monoclonal antibody already in the pipeline that may be able to offset lean-muscle loss