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A subsequent multicenter Phase 2 trial in participants with overweight or obesity reported approximately 15.6% mean body weight reduction at 32 weeks with cagrilintide 2.4 mg plus semaglutide 2.4 mg, compared to roughly 5.1% with placebo and lower percentages with either monotherapy

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HEK293 cells transfected with SNAP-ghrelin receptor (WT or mutants) were seeded at a density of 1 10 6 cells into 3 cm dish and incubated for 24 h at 37 C in 5% CO 2

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