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While NMDA receptors allow entry of Ca 2+ , AMPA receptors heterotetramer, which consists of four glutamate receptor subunits (GluR1-4), mediate the entry of Na + current into the neuron, thus resulting in rapid signal transmission ( Ketamine: One Drug, Many Uses Originally approved in 1970 as an anesthetic, ketamine thereafter earned notoriety as a recreational drug of abuse (Special K) because of its dissociative effects

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EC 50 -values were determined from the concentration-response curves using a three-parameter logistic equation