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Sulforaphane (a glucosinolate compound found in some cruciferous vegetables like broccoli) is one of the most commonly cited natural Nrf2 activators, though there are many others shown to have similar effects on Nrf2-induced enzymatic activities and metabolites

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This reduction was not only accompanied by downregulation of endogenous mouse ApoE expression in the brain, but also decreased the levels of synaptic glutamate receptors, presynaptic protein -syn [89]