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Chronic central infusions of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats

NF-B inhibition by the binding of taurochenodeoxycholic acid to TGR5 has also been shown to drastically reduce inflammatory phenotypes among astrocytes during experimental autoimmune encephalomyelitis [228]

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The damage may have been caused by a tumor or the surgery or radiation therapy that was performed to treat the tumor