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Acne, accelerated male-pattern hair loss, and in women virilisation (masculinising effects including voice deepening and clitoral enlargement) are androgenic effects that vary by compound but cannot be entirely eliminated

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These mechanisms, however, appear to be different than the means by which LPS and systemic inflammation increase paracellular permeability and should not be interpreted as equivalent

Prevention and treatment Diet Including foods with vitamin B12 and folate (listed above) in the diet is the first step to preventing and treating low levels of these vitamins