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Stage IV In stage IV, the tumor has spread to other parts of the body, such as the lung or liver

Additionally, caution should be exercised in patients with a history of pancreatitis, gastroparesis, or hypersensitivity to any of the GLP-1 receptor agonist components

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In 2024, a large study of over 160,000 individuals showed that GLP-1RAs are associated with a 195% higher risk of major depression, 108% increased risk for anxiety, and 106% elevated risk for suicidal behavior