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In some tissues and organs, including the heart, both eNOS and neuronal NOS are present
For example, a kainite-model of TLE showed that seizures increased the steady-state mitochondrial ROS levels in the forebrain, which caused deficits in mitochondrial respiration, exemplified by the significant reduction of oxygen consumption by hippocampal neurons ( Discussion The complex and elaborate nature of cortical development, during which a large amount of ATP is produced and utilized, necessitates a deeper understanding of metabolized macromolecules and the mitochondria
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5.1 Preserving the GSH/GSSG Redox State Across Sample Matrices Preanalytical oxidation is a major source of error in GSH/GSSG analysis
It means the compounds effects are transient and it clears the system quickly once administration stops
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