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Some individuals experience reduced hunger almost immediately, while others may take longer to see a significant change in cravings and portion control

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Many early peptide programs relied on acute or high-dose administration, which produced adverse effects unrelated to therapeutic exposure levels

But risk of unknown long-term effects, risk of interactions with medications we haven't tested, risk of immune sensitization after repeated dosing, and risk of phosphate imbalances in individuals with compromised renal function

This review summarizes the most recent data on the epidemiology of MASLD