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Months 2-3: Cellular signaling continues to accumulate

10.1111/cns.13548 365 Ramos-CejudoJ.WisniewskiT.MarmarC.ZetterbergH.BlennowK.de LeonM

Biochim Biophys Acta 268:305312 Terai Y, Ueno H, Ogawa T, Sawa Y, Miyagi A, Kawai-Yamada M, Ishikawa T, Maruta T (2020) Dehydroascorbate reductases and glutathione set a threshold for high-lightinduced ascorbate accumulation

In diabetic patients, hyperglycemia and other metabolic abnormalities cause oxidative stress and mitochondrial damage in renal TECs, thereby activating apoptotic pathways

This pathological process could impair pulmonary and hepatic function, partially due to the high expression of angiotensin-converting enzyme 2 (ACE2) receptors in these organs ( While existing ML approaches for predicting hepatic toxicity have provided important mechanistic insights through modeling, significant translational limitations persist (60)