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For example, in about half of individuals with autism, supplementing with B6 helps decrease behavioral problems, possibly because it helps produce neurotransmitters ( Research also suggests that taking 5080 mg of B6 supplements daily may help with symptoms of premenstrual syndrome (PMS), such as moodiness, irritability, anxiety and depression ( One possible reason B6 may help with PMS is because it helps make serotonin, which lifts your mood