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Vomiting was reported in 25/140 (18%) VK2735-treated patients compared with none reported among patients receiving placebo

This has, as a consequence, the interference with the adaptive metabolic reprogramming in prostate cancer cells (Valentino et al., 2017)

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Research on the safety and efficacy of such combinations is a critical area of study ( in silico molecular docking results indicated that sitagliptin may exhibit putative binding affinities with the DPP4/CTNNB1/MET signatures, surpassing those of standard inhibitors for these genes