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Tirzepatide promotes natriuresis (sodium excretion through urine), which reduces intravascular volume

In six healthy (free-living, fertile) US men, a diet with a high Se intake (~200 g/day for ~100 days, mostly through Se-rich beef and rice) decreased concentration and total number of sperm, the proportion of motile, progressive, headless sperm, and tail defects, and increased the proportion of tailless sperm (185)

The approval was based on a series of studies, including a pivotal Phase III trial assessing the vaccines consistency, immunogenicity and safety in healthy adults

doi: 10.1210/er.2009-0041 4 GallandSGeorgesBLe BorgneFConductierGDiasJVDemarquoyJ