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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (36, 83)

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One study with volunteers found even people without sensitive skin experienced a significant reduction in stratum corneum integrity and induced mild erythema

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New research has highlighted other important aspects: its effects on stabilizing blood sugar levels (insulin resistance, adjusting blood fat levels), increasing fertility and protecting the nervous system have innovative potential