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The peptides acidic residues (glutamate at position 2 and aspartate at position 3) have been proposed to facilitate interactions with chromatin-associated proteins and transcription regulatory complexes, consistent with observed epigenetic effects documented in in-vitro model systems

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Figure 1 2.1 The mechanism of ferroptosis 2.1.1 The GPX4/GSH signaling pathway in ferroptosis GSH is the primary antioxidant involved in intracellular antioxidant stress, participating in numerous essential cellular metabolic activities such as the removal of ROS, DNA and protein synthesis, and signal transduction

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