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Your brain is incredibly smartif it detects a significant energy deficit, it will eventually flip a survival switch that no medication can fully override

Consequently, the corrective effects of metabolic reprogramming may depend on disease stage and cell-type composition (86)

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Several papers point to a preservation or increase in lean body mass.21 One even showed improvements in muscle composition (a decrease in muscle fat) in non-diabetic participants.27 Others have seen a reduction of lean body mass, making up around 20-50% of total weight lost, but its important to note that this was a review of research into several anti-diabetic drugs including some that arent GLP-1 RAs.26 Research into low-calorie diets reveals that exercise and a high protein intake can help preserve muscle mass and even build muscle while restricting calories, so you cant just eat junk, not exercise, and still expect these drugs to work miracles.22 Your overall health can improve by adding exercise and a healthy, protein-rich diet to a GLP-1 RA routine