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"Computer-based studies such as ours have key advantages, such as reductions in costs and time, rapid analysis of large data sets, flexibility in experimental design and the ability to identify and mitigate any ethical and safety risks before conducting experiments in the laboratory
The de novo thymidylate (dTMP) biosynthesis pathway involves three enzymes: dihydrofolate reductase (DHFR), serine hydroxymethyltransferase (SHMT), and thymidylate synthase (TYMS) ( Figure 3 )
Melanotan 2 is a 7-amino acid cyclic lactam analogue of -MSH, originally synthesised at the University of Arizona by Hruby and colleagues as part of a programme to develop stable, potent melanocortin receptor agonists for photoprotection and pigmentation research
As GLP-1 agonists contribute to glycaemic control by potentiating glucose-dependent stimulation of insulin secretion from pancreatic cells 21 , we compared the effects of the biased agonist P5 with Ex4 on plasma insulin levels in response to the glucose challenge
