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The practical questions researchers ask are always the same: how much per day, and by what route

Drug Interactions The concomitant use of XIGDUO XR with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation (e.g., cationic drugs) [see DRUG INTERACTIONS ]

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[DOI] [PubMed] [Google Scholar] 23.Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzlez-Barn M

So you slow down eating and eventually stop because you feel satisfied