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Therefore, modulating copper homeostasis and cuproptosis addresses a novel pathogenic axis that is not directly targeted by existing first-line drugs, suggesting the potential for synergistic or personalized therapeutic strategies

Abdel-Haq R, Schlachetzki JCM, Glass CK, Mazmanian SK

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S-nitrosylation involves the transfer of NO to one or more cysteine thiol groups and it occurs when there is an increased production of RNS during oxidative stress (Conway and Harris, 2015)