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doi:10.1016/j.clim.2020.108544 122 Schloss, J., Leach, M., Brown, D., Hannan, N., Kendall-Reed, P

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Oral preparations of Vitamin B12 may increase serum levels but many patients remain symptomatic until they use sublingual or vitamin B12 injections due to low cellular concentrations 6

Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women

Other groups found similar outcomes that linked the GPx3 locus to ALS but were also able to demonstrate that lower GPx3 levels strongly correlated with more advanced disease, in addition to showing significant motor deficits in a knockdown zebra fish model 21