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Attenuated Toxoplasma gondii enhances the antitumor efficacy of anti-PD1 antibody by altering the tumor microenvironment in a pancreatic cancer mouse model

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The glucagon receptor component adds energy expenditure and lipolysis effects not seen in dual agonists, which may explain the larger effect sizes in Phase II data

The metabolic adaptations that tirzepatide supported, improved insulin sensitivity, reduced lipogenesis, enhanced satiety signaling, gradually revert toward pre-treatment baselines