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However, exposure to high glucose conditions did increase mRNA expression and membrane-bound DPP-4 activity in human glomerular (76) and dermal (77) microvascular endothelial cells in vitro , although, interestingly, not in macrovascular (human aortic) endothelial cells (77)

[DOI] [PubMed] [Google Scholar] 5.Syndromes of thrombotic microangiopathy

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For injectable semaglutide, one small human study didnt detect the medication in breast milk, although levels may have been too low to be detected by the testing tools used