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Amongst the studied patients, only (15.3%) of the participants had normal vitamin D serum level while more than half of them (53.5%) with vitamin D deficiency and (31.2%) insufficient Vitamin D

Although phase-2 studies indicated some positive outcomes of ipamorelin for this condition, the benefits observed over 7-10 days were not considered substantial, leading to the discontinuation of clinical development [14, 15]

doi:10.1098/rsif.2010.0285

Ethics declarations Acknowledgements Some of the data were presented as an abstract at the American Gastroenterological Association meeting in 2023

doi: 10.1093/ndt/gfad009 154 GragnanoFDe SioVCalabrP