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The change in group-level Schirmer values reached a borderline significant p-value (p = 0.054), however, considering the small sample size, the significant correlation with multiple cytokines at the V3 time point supports the efficacy of the combined treatment with GSH-C4

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As a consequence of low glutathione and the lack of negative feedback, an increase of -glutamyl-cysteine production takes place

doi: 10.1001/jamaneurol.2017.3475