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Since the contaminated soil is handled directly at the source of the pollution, it is less expensive than ex-situ BioR methods

Possible effects include: Loose or excess skin Fatigue Hair thinning Muscle loss (if not strength training) Gallbladder issues with rapid loss Nutrient deficiencies if diet is poor Most risks are reduced with gradual weight loss, adequate protein, strength training, and medical supervision

Begin CLA at a lower fraction of the commonly studied dose and gradually increase toward 3.2 grams per day if metabolic markers remain stable

Patwardhan RS, Sharma D, Checker R, Thoh M, Sandur SK

A meta-analysis published in 2023 that included this trial and four other treatment trials conducted since that time concluded that duloxetine is only associated with a modest trend toward pain reduction and that this is accompanied by a similar trend in increased adverse events, suggesting a need for additional well-designed trials to support its continued use in this setting (Chow 2023)