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By inhibiting Gwt1, Fosmanogepix disrupts the anchoring of mannoproteins on the fungal surface, impairing growth and pathogenicity through a mechanism distinct from azoles and echinocandins, thereby reducing the likelihood of cross-resistance (Pappas et al., 2023)

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however, a poor tolerance of liquid nutrition predicts possible oral nutrition failure

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Despite these promising results, the researchers said this study drew people from a small geographic region from within a single health system and its participants were predominantly white, which could limit the ability to translate these findings to other geographies or ethnic groups