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Key Takeaways Obesity increases visceral fat levels, which can disrupt normal hormonal function

Some participants naturally increased their activity as weight dropped

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Most trials and preclinical studies do not demonstrate consistent or clinically meaningful body-weight loss, suggesting a relatively weak impact on appetite regulation and energy balance, and where follow-up has been performed, beneficial effects tend to attenuate after discontinuation of the intervention (Soltani et al., 2023)