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(PubMed) Bianchini F, Vainio H

The GSH/GPX4 node is the crucial regulator of ferroptosis The GSH system, as a lipid peroxide scavenger, has attracted much attention as a potential therapeutic target for ferroptosis

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In contrast, short-acting formulations such as exenatide and the older-generation agent lixisenatide are now prescribed far less frequently, and several formulations have been withdrawn from the market in certain countries, largely due to limited clinical uptake, the availability of more effective long-acting alternatives, and commercial considerations rather than confirmed safety concerns