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Also, an enzyme located in the mucous membrane of the intestines, or enterocytes, which are more susceptible to oxidant damage, can be inactivated to a larger extent leading to variation in the results of its determination

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Undermethylation Some patients with an undermethylated mood pattern report worsening of depression, agitation or obsessive symptoms with folic acid or methylfolate despite their biochemical role in one-carbon metabolism

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