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In controlled laboratory settings, GLP-1 receptor activation has been associated with: Reductions in alcohol intake Decreased opioid-seeking behaviors Lower rates of binge-like consumption patterns However, findings from animal models do not always translate directly to human outcomes

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Nature 393:7276 Belgardt BF, Brning JC (2010) CNS leptin and insulin action in the control of energy homeostasis

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However, a 2024 double-blind randomised trial in women with PCOS found no pregnancy-rate benefit during controlled ovarian stimulation