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It is the predominant intracellular non-protein thiol in mammalian tissues, present at concentrations typically ranging from 110 mM in the cytosol, with particularly high concentrations in the liver (up to 10 mM), which is the primary site of GSH synthesis and export

Topiramate is often used as an adjunct medication rather than the sole therapy

In contrast to class I GRXs, which are glutathionylated at Cys A over a wide range of GSH/GSSG redox potentials, only the internal disulfide-containing oxidized form is detected for ROXY9 at a midpoint redox potential between 220 and 230 mV at p H 7.0

Specifically, it helps transport fatty acids into the mitochondria, where they are used in energy production

No obstante, no se recogieron datos de variables con mayor relevancia clnica, como la ganancia ponderal