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It represents the complete or partial loss of a body extremity, either through elective surgery (surgical/therapeutic amputation) or as the direct result of a traumatic injury (traumatic amputation)

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DALLAS, April 29, 2025 Glucagon-like peptide-1/gastric inhibitory polypeptide (GLP-1/GIP) agonists originally developed to treat people with diabetes and obesity are showing promise for improving cardiovascular outcomes, but their effects can vary across different populations[1]

GLP-1 receptor agonists do not directly increase serotonin, so they carry minimal risk of triggering serotonin syndrome when combined with Zoloft at standard therapeutic doses

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