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Notably, the combination of JHU083 plus anti-PD1 or JHU083 plus anti-PD1 plus anti-CTLA4 resulted in greater inhibition of tumor growth and enhanced survival, suggesting an additive effect of combining metabolic therapy with checkpoint blockade (Supplemental Figure 6, A and B)

Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation

Antioxidant Protection If youve ever made a fruit salad, you likely know the chefs trick to sprinkling a little lemon or lime juice over the fruit to keep it from turning brown

Kirwan CJ

PMCID: PMC5664422