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Rather than choosing, consider formulas that combine both to potentially access a wider range of benefits

Its design incorporates non-natural amino acid residues such as 2-naphthylalanine and aminobutyric acid (Aib) , which enhance receptor selectivity and stability

A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

doi: PubMed: 19139406

That small molecular size is the defining advantage: these peptide fragments can cross the blood-brain barrier and interact directly with neurons, something that most endogenous neurotrophic factors cannot do on their own