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doi:10.1016/S2468-1253(24)00390-X

For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%

MCAS and histamine intolerance require careful history, trigger review, medication review, diet context, and sometimes laboratory evaluation or specialist collaboration

If cold water sloshes in your stomach, try room-temperature water

This approach may be more widely useful as a conformational sensor for other GPCRs, although it lacks the ability to detect changes at the receptor intracellular face that are needed to provide insights into conformational changes required for G protein interactions