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The goal is not to lose weight indefinitely it is to reach a sustainable body composition and maintain it

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Creatine also supports muscle cell volumization and reduces protein degradationboth critical during periods of caloric restriction

Current UK practice, as reflected in guidance from the Centre for Perioperative Care (CPOC) and the Joint British Diabetes Societies (JBDS), generally supports continuing GLP-1 receptor agonists perioperatively for most patients, with appropriate risk assessment and precautions

In rodent models, peripheral administration of exendin-4 (EX4), a GLP-1RA has been shown to reduce motivation for sucrose, as evidenced by decreased responding in progressive ratio operant-conditioning tasks (Dickson et al., 2012)