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Clinical studies have raised concerns regarding reductions in lean body mass during GLP-1RA therapy [40], whereas preclinical studies report improvements in muscle mass and strength [41,42,43]

Most patients notice changes in appetite and gradual weight reduction within the first few weeks, but significant results often appear over several months

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Management Strategies for Bloating When taking semaglutide, bloating can be an uncomfortable side effect for some individuals

A recent historical cohort study examining patients with mood disorders receiving lithium found that SGLT2 inhibitor use was associated with measurable changes in renal function parameters, underscoring the need for careful monitoring when these medications are co-prescribed [70]