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In a clinical study involving patients with type 2 diabetes, an almond-based diet with a low-carbohydrate content, which had been previously shown to possess marked prebiotic properties [110, 111], resulted in augmentation of the number of SCFA-producing bacteria species, such as Roseburia , Ruminococcus and Eubacterium , which led to an increase in fasting blood GLP-1 levels and also promoted antidepressive effects after three months [112]

The FDA also announced plans for a subsequent advisory review that will include Melanotan II among additional peptide-related substances

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