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There was a tendency toward higher t 1/2 with increasing hepatic impairment, but applying the same rationale as stated above for participants with renal impairment, this was not considered clinically relevant

Via glutathione-S-transferases, GSH conjugates with xenobiotics, heavy metals and electrophilic metabolites, making them water-soluble and eliminable (mercapturic acid pathway)

PubMed: 4370008 Classic reference for splanchnic vasoconstriction during exercise

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