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J Berry Research

PMCID: PMC10385428

American journal of clinical dermatology [Internet]

9% use it for 45+ days[] These safe therapeutic doses can significantly deplete glutathione in women who already have low baseline levels.[] Healthy individuals can tolerate up to 4g/day with only modest glutathione decrease, but individuals with compromised glutathione experience significant depletion even at therapeutic doses

Of particular note, the dopamine levels encountered by immune cells in the CNS are very likely to be increased in the context of SUDs, as all addictive substances acutely increase CNS dopamine in the mesocorticolimbic system, as well as other brain regions (Di Chiara and Imperato, 1988