Figure from van der Aart-van der Beek AB, Nat Rev Nephrol, 2020 The Study Methods This was an international, event-driven, double-blind, parallel-group, randomized, placebo-controlled trial conducted at 387 sites in 28 countries comparing semaglutide to placebo in patients with T2DM and CKD, both being treated with baseline standard of care
Compounded semaglutide from licensed 503A pharmacies must be stored at 36F to 46F (2C to 8C) before use
Because tirzepatide activates two receptors rather than one, the biological response to reduced exposure may not mirror semaglutide directly
Please contact your doctor ASAP and seek in-person care immediately if a side effect becomes problematic or you experience: Severe nausea and/or vomiting resulting in dehydration- it is important to stay well hydrated and drink plenty of fluids while on this medication Kidney problems/kidney failure - vomiting, nausea, diarrhea can cause dehydration and kidney issues and make kidney problems worse in individuals who have pre-existing kidney conditions
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