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Indeed, one study reported that thioredoxin 1 ( trxA ) is induced at low growth rates via the stringent response, as if nutritional inadequacy somehow requires a boost in redoxin activity ( Alternatively, these redoxins may not be generalists, like Trx1, but may have specific client proteins whose function happens to be expendable in our growth medium

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Chandrawati R, Caruso F

All these mechanisms lead to MS-like motor symptoms observed in patients with Cbl deficiency such as subacute degeneration of the spinal cord [84]