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Preclinical studies have shown that cobalamin inhibits glutamate exocytosis, as an excitatory pain neurotransmitter, and when infused intracerebroventricularly, increases GABA cell contents, as an inhibitory pain neurotransmitter [6, 9]

doi:10.1016/j.bmcl.2018.07.009

Trigeminal neuralgia can also be caused by nerve damage sustained after surgery

[4] Important unanswered questions include: Whether other laboratories can repeat the FBXO22BACH1 findings

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