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Thus, the authors demonstrate the presence of GSTM1-1 in liver and conclude that the alkylation and potential irreversible inactivation of this isoform in vivo could contribute to an understanding of the hepatotoxicity associated with zileuton [55]

DOI:10.1111/j.1467-2494.2005.00235.x [ Links ] 22

Furthermore, the membrane-stabilizing effect of GSH application could be a main protective mechanism for GSH-induced LT stress relief

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The copper ion is chelated primarily through the imidazole nitrogen of histidine and the alpha-amino nitrogen of glycine, creating a stable, biologically active complex