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This challenge was realized using duodenocutaneous fistulas in rats and the parallel therapy, likely related to nitric oxide (NO)-system, the stable pentadecapeptide BPC 157, (4-9) (an anti-ulcer peptide supposed to be novel mediator of Roberts cytoprotection (as stable in human gastric juice more than 24 hours)) (4-9), known to heal fistulas (10-12) and skin wounds (13-15), the nitric-oxide synthase (NOS)-substrate L-arginine and/or the NOS-inhibitor L-nitro-arginine methyl ester (L-NAME)

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Peptides that promote angiogenesis restore blood flow to damaged nerves, creating the metabolic conditions necessary for regeneration

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